Physicochemical and stability profile of castor oil emulsions stabilized using natural and synthetic emulsifiers

نویسندگان

چکیده

Background: The quality and stability of castor oil emulsions may be influenced by the type amount its constituent emulsifiers. To our knowledge, emulsifying potential single, double, triple-emulsifier systems comprising Tween 20, acacia gum methyl cellulose have never been compared. aim work was to formulate stabilized using natural and/or synthetic agents evaluate their organoleptic, physicochemical, profiles. Methods: Six types were prepared spontaneous emulsification method, characterised in terms physical properties; centrifugation analysis, real-time profile at 25 ℃ 40 for 90 days. Results: FT-IR analysis suggested that compatible with all studied 20-stabilised formulation (F2) gum/methyl cellulose-based samples (F5) exhibited unacceptable organoleptic attributes properties. properties remaining macroemulsions satisfactory: pH (6.2 7.0); electrical conductivity (2253-4557 µS/cm); spreadability (0.7-2.1 cm); globule size (2.73-3.74 µm), creaming index (9-18 %). varying degree instability over time elevated temperatures. most promising emulsion cellulose/tween sample F7: pH: 6.9, conductivity: 4557 µS/cm, spreadability: 1.37 cm, size: 3.74 µm, index: 9 %, satisfactory °C °C. Conclusion: Sample F7 serve as cream base dermal transdermal delivery active pharmaceutical ingredients intended treat various local skin problems systemic diseases.

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ژورنال

عنوان ژورنال: World Journal of Biology Pharmacy and Health Sciences

سال: 2022

ISSN: ['2582-5542']

DOI: https://doi.org/10.30574/wjbphs.2022.9.2.0043